Welcome

Hi! I am Tania Wang, Welcome to my personal website.

Research Interests

Biomedical informatics, computational biology, functional genomics, immunotherapy and developmental neurobiology; focusing on cancer and neurodevelopmental disorders; interfacing biomedical science with machine learning, algorithms, and omics.

Work Experience

2023.08 - now Peking University Third Hospital, PUTH

2023.08 - now    Postdoctoral Fellow

2019.03 - 2019.08 Beijing Institutes of Life Science, CAS

2019.03 - 2019.08   Bioinformatics Engineer

2014.07 - 2019.02 AccuraScience, LLC

2015.05 - 2019.02   Project Supervisor

2014.07 - 2015.05   Bioinformatics Engineer

Education

2019.09 - 2023.07: Ph.D, School of Life Sciences, CSU, Changsha/Beijing Institutes of Life Science, CAS, Beijing, P. R. China, Genetics.

2011.09 - 2014.06: M.S., Wenzhou Medical University, Wenzhou, P. R. China, Genetics.

2006.09 - 2010.06: B.S., Chongqing University of Posts and Telecommunications, Chongqing, P. R. China, Bioinformatics.

Bioinformatics Tools, Databases and Pipelines

1. OncoVar
2. AI-Driver
3. RRBS-analyser

Publications

1. Wang T, Liu L, Fan T, Xia K, Sun Z. Shared and divergent contribution of vitamin A and oxytocin to the aetiology of autism spectrum disorder. Comput Struct Biotechnol J. 2023 May 16;21:3109-3123. doi: 10.1016/j.csbj.2023.05.015. PMID: 38213898; PMCID: PMC10782014. pdf download
2. Dai J, Wang T, Xu K, Sun Y, Li Z, Chen P, Wang H, Wu D, Chen Y, Xiao L, Liu H, Wei H, Li R, Peng L, Yu T, Wang Y, Sun Z, Wang DW. Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature. Front Med. 2023 Aug;17(4):768-780. doi: 10.1007/s11684-023-0982-1. Epub 2023 May 1. PMID: 37121957. pdf download
3. Ran X, Xiao J, Cheng F, Wang T, Teng H, Sun Z. Pan-cancer analyses of synonymous mutations based on tissue-specific codon optimality. Comput Struct Biotechnol J. 2022 Jul 6;20:3567-3580. doi: 10.1016/j.csbj.2022.07.005. PMID: 35860410; PMCID: PMC9287186. pdf download
4. Wang T, Zhao T, Liu L, Teng H, Fan T, Li Y, Wang Y, Li J, Xia K, Sun Z. Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder. EBioMedicine. 2022 Jul;81:104091. doi: 10.1016/j.ebiom.2022.104091. Epub 2022 Jun 2. PMID: 35665681; PMCID: PMC9301877. pdf download
5. Song W, Li Q, Wang T, Li Y, Fan T, Zhang J, Wang Q, Pan J, Dong Q, Sun ZS, Wang Y. Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders. Brain Behav Immun. 2022 May;102:237-250. doi: 10.1016/j.bbi.2022.02.027. Epub 2022 Mar 1. PMID: 35245678. pdf download
6. Wang T, Zhang Y, Liu L, Wang Y, Chen H, Fan T, Li J, Xia K, Sun Z. Targeted sequencing and integrative analysis of 3,195 Chinese patients with neurodevelopmental disorders prioritized 26 novel candidate genes. J GENET GENOMICS. 2021 Apr 20;48(4):312-323. doi: 10.1016/j.jgg.2021.03.002. Epub 2021 Apr 1. PMID: 33994118. pdf download
7. Zhang Y, Wang T, Wang Y, Xia K, Li J, Sun Z. Targeted sequencing and integrative analysis to prioritize candidate genes in neurodevelopmental disorders. Mol Neurobiol. 2021 Apr 15. doi: 10.1007/s12035-021-02377-y. Epub 2021 Apr 15. PMID: 33860439; PMCID: PMC8280036. pdf download
8. Wang T, Ruan S, Zhao X, Shi X, Teng H, Zhong J, You M, Xia K, Sun Z, Mao F. OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers. Nucleic Acids Res. 2021 Jan 8;49(D1):D1289-D1301. doi: 10.1093/nar/gkaa1033. PMID: 33179738; PMCID: PMC7778899. pdf download
9. Li QS, Sun Y, Wang T. Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions. Clin Epigenetics. 2020 Oct 17;12(1):149. doi: 10.1186/s13148-020-00944-z. PMID: 33069246; PMCID: PMC7568396. pdf download
10. Wang H, Wang T, Zhao X, Wu H, You M, Sun Z, Mao F. AI-Driver: an ensemble method for identifying driver mutations in personal cancer genomes. NAR Genom Bioinform. 2020 Oct 13;2(4):lqaa084. doi: 10.1093/nargab/lqaa084. PMID: 33575629; PMCID: PMC7671397. pdf download
11. Robakis TK, Zhang S, Rasgon NL, Li T, Wang T, Roth MC, Humphreys KL, Gotlib IH, Ho M, Khechaduri A, Watson K, Roat-Shumway S, Budhan VV, Davis KN, Crowe SD, Ellie Williams K, Urban AE. Epigenetic signatures of attachment insecurity and childhood adversity provide evidence for role transition in the pathogenesis of perinatal depression. Transl Psychiatry. 2020 Feb 3;10(1):48. doi: 10.1038/s41398-020-0703-3. PMID: 32066670; PMCID: PMC7026105. pdf download
12. Wu J, Yu P, Jin X, Xu X, Li J, Li Z, Wang M, Wang T, Wu X, Jiang Y, Cai W, Mei J, Min Q, Xu Q, Zhou B, Guo H, Wang P, Zhou W, Hu Z, Li Y, Cai T, Wang Y, Xia K, Jiang YH, Sun ZS. Genomic landscapes of Chinese sporadic autism spectrum disorders revealed by whole-genome sequencing. J Genet Genomics. 2018 Oct 20;45(10):527-538. doi: 10.1016/j.jgg.2018.09.002. Epub 2018 Oct 21. PMID: 30392784. pdf download
13. Li J, Jiang Y, Wang T, Chen H, Xie Q, Shao Q, Ran X, Xia K, Sun ZS, Wu J. mirTrios: an integrated pipeline for detection of de novo and rare inherited mutations from trios-based next-generation sequencing. J Med Genet. 2015 Apr;52(4):275-81. doi: 10.1136/jmedgenet-2014-102656. Epub 2015 Jan 16. PMID: 25596308. pdf download
14. Wang T, Liu Q, Li X, Wang X, Li J, Zhu X, Sun ZS, Wu J. RRBS-analyser: a comprehensive web server for reduced representation bisulfite sequencing data analysis. Hum Mutat. 2013 Dec;34(12):1606-10. doi: 10.1002/humu.22444. Epub 2013 Oct 10. PMID: 24106010. pdf download
15. Wang M, Fan X, Wang T, Wu J. High-throughput sequencing of autism spectrum disorders comes of age. Genet Res (Camb). 2013 Aug;95(4):121-9. doi: 10.1017/S0016672313000153. PMID: 24074369. pdf download
16. Teng H, Cai W, Zeng K, Mao F, You M, Wang T, Zhao F, Sun Z. Genome-wide identification and divergent transcriptional expression of StAR-related lipid transfer (START) genes in teleosts. Gene. 2013 Apr 25;519(1):18-25. doi: 10.1016/j.gene.2013.01.058. Epub 2013 Feb 13. PMID: 23415839. pdf download
17. Wu J, Liu Q, Wang X, Zheng J, Wang T, You M, Sheng Sun Z, Shi Q. mirTools 2.0 for non-coding RNA discovery, profiling, and functional annotation based on high-throughput sequencing. RNA Biol. 2013 Jul;10(7):1087-92. doi: 10.4161/rna.25193. Epub 2013 May 29. PMID: 23778453; PMCID: PMC3849156. pdf download